Mr Run’s HMB – Protect, Build & Maintain
Recommended by The International Society of Sports Nutrition
✔ Protects muscle & speeds up recovery
✔ Improves strength, fitness and endurance
✔ Helps lean muscle growth & accelerates fat loss
✔ Reduces age-related loss of muscle
FREE shipping to all UK destinations.
Athlete’s Best Kept Secret
A powerhouse for your body, HMB is clinically proven to improve fitness and athletic performance and to speed up recovery times. It supports the growth of lean muscle while protecting and repairing muscles from exercise-induced damage.
To be taken as a pre or post workout or as a general daily supplement to limit muscle loss due to excessive training, ageing, inactivity or low calorie diets.
WHAT IS HMB
HMB, full name beta-hydroxy beta-methylbutyrate, is a substance produced by the body naturally through breakdown of leucine, an amino acid found in food protein. However, since only a small percentage of leucine is converted to HMB, it is not possible to obtain significant amounts from diet alone.
During periods of intensive training or calorie cutting we use up more HMB and our body’s production of it is not able to keep up with the demand.
Our body’s production of HMB declines with age – the older we are the less HMB we make.
🔶 PROTECTION, REPAIR AND GROWTH OF LEAN MUSCLE – HMB has a positive effect on body composition and strength due to its anabolic and anti catabolic properties – it protects our muscles from wear-and-tear damage and stimulates their growth, repair and recovery.
🔶 IDEAL FOR ENDURANCE TRAINING – HMB improves V02 max and raises ATP levels, thus increasing cardio aerobic capacity and resistance to fatigue. Meaning that it can help you go stronger for longer, with less effort.
🔶 REDUCES AGE-RELATED MUSCLE LOSS – As we age our bodies start to lose bone density, muscle definition and muscle mass. HMB has been shown to limit this decline.
🔶 SUPPORTS JOINT FLEXIBILITY AND BONE STRENGTH – HMB assists in the formation of collagen in the bones and connective tissue. It improves joint flexibility so stiff joints won’t delay your return to training.
🔶 IMPROVES EFFICIENCY OF PROTEIN FROM DIET – HMB mimics the effects of a high protein diet. When taking HMB as a supplement it is possible to limit our daily protein intake up to 1 gram per kilogram of body weight, while maintaining results similar to a diet that is very high in protein.
🔶 SPEEDS UP FAT LOSS – HMB makes sure your body takes its energy from fat stores rather than from muscles when you are training hard or dieting. It is therefore a perfect addition to any weight loss regime or during cycles of calorie cutting, when you are at risk of muscle loss.
🔶 BACKED BY SCIENCE – Hundreds of studies have been carried out on the effects of HMB. In 2013 The International Society of Sports Nutrition officially recommended HMB, based on the strength of evidence of its benefits.
🔶 A PERFECT SUPPLEMENT FOR ATHLETES – Regardless of age, sex or fitness level, HMB is an ideal supplement for running, cycling, swimming, fitness and gym training, weight lifting, combat sports like boxing or MMA, team sports, hiking, climbing, rowing, tennis, and any other sport discipline or strenuous physical activity.
MR RUN’S HMB
Mr Run’s HMB provides you with a highly concentrated, scientifically-proven dose of HMB in a convenient and affordable capsule form. It contains zero calories and can be used as part of any diet or fat loss regime. Gelatin-free encapsulation is suitable for vegans. Manufactured in the UK to the highest standards of quality and good manufacturing practices and is free from any fillers, bulking agents and colourings, meaning you get only the purest, best quality HMB.
Calcium ß-hydroxy-ß-methylbutyrate (HMB) – 500mg per capsule.
Other ingredients: Vegetarian capsule shell
120 capsules per pack.
SUGGESTED USE FOR SHORT TERM/LOADING PHASE
When taking HMB for the first time or during a period of intensive physical activity, for example during marathon training, take 3 grams (6 capsules) per day in divided doses for 12 weeks.
For optimal benefits take one dose of 2 capsules one hour before training/exercise, and take the last dose of 2 capsules before bedtime. Third dose of 2 capsules can be taken at any point during the day.
SUGGESTED USE FOR LONG TERM MAINTENANCE
2 capsules per day. For optimal benefits take either one hour before training/workout, or just before bedtime.
Reduces Exercise-Induced Muscle Damage and speeds up recovery
During exercise our cells get damaged and then grow back over time. HMB limits this damage so you don’t need as much time to recover and get back to hitting your goals.
increases energy metabolism and Aerobic Endurance
HMB supplementation has been shown to increase power output and improve VO2 max – utilisation of oxygen by your body – making physically-demanding exercise feel easier.
Enables Faster Fat Loss whilst protecting lean muscle mass
HMB works by taking energy from fat stores in the body rather than from muscles. This means it can help you get slimmer, stronger and be in the best shape of your life.
Improves Joint Flexibility and strengthens bone
Shown to play a beneficial role in the formation of collagen in the bones and connective tissue, HMB improves joint flexibility so stiff joints won’t delay your return to training.
What types of athletes is hmb best for?
Effects of HMB on athletic performance has been studied in many various sports disciplines.
It has been found to increase muscle strength, speed and endurance in: swimmers, runners, climbers, rowers, tennis players, combat sport athletes, people engaging in military training, crossfit or high-intensity interval training HIIT training, body builders, rugby, soccer and football players.
What makes hmb one of the best supplements for runners?
HMB is also an ideal supplement for runners who are combining running with resistance and strength exercise.
I only engage in recreational sport activities and light exercise. Should I still take hmb?
Are there any other benefits of hmb?
HMB has many benefits, including, fat reduction, muscle building, increasing your V̇O₂, and limiting damage to muscles. Studies have also shown that there are secondary benefits including an improvement in bone density, bone fracture recovery, wound healing, and lower blood pressure.
Will taking hmb grow muscles for me?
How exactly can hmb help me lose weight?
What else is known about the energising effects of hmb? Does it play a role in mitochondria?
What are the benefits of hmb for older people?
Studies performed with older people have demonstrated that HMB can debilitate the development of sarcopenia (loss of muscle mass) in the elderly.
Another study has shown that HMB supplementation may mitigate age-related brain impairment such as information processing, mental operation, or intellectual activity such as thinking, reasoning, remembering, imagining, or learning and may therefore be an effective tool to combat undesirable features of the ageing process.
Supplementing HMB also reduces weakness and loss of muscle that occurs due to long periods of inactivity, for example after illness or surgery.
Is it true that hmb lowers inflammation?
HMB improves muscle function not only by promoting muscle protein synthesis but also by preventing muscle damage through its antioxidant and anti-inflammatory effect.
What else? What do we still need to learn about hmb?
After it became clear that HMB improves athletic performance and functioning of muscles and joints, some clever scientists and doctors thought to check if it could be helpful for other things in the body. Recent research done in animals has shown that:
• HMB prevents age-related cognitive decline – the findings of animal studies suggest that prolonged HMB supplementation starting in adulthood may preserve cognition with age
• Following gastrointestinal infection, HMB supplementation lowered inflammation and improved gut recovery
• HMB protected the liver and reduced liver inflammation after bacterial infection
• HMB prevents hormonal-related bone loss
• When given to pregnant animals, HMB improved bone density and skeleton structure in both mothers and in their offspring
• In one study HMB was given to animals who were fed very high-fat diets. In normal circumstances such a diet causes animals to become obese and develop metabolic disorders – diabetes and high blood pressure. However in this case HMB reversed obesity and lowered the risk of diabetes and high blood pressure.
This research is still developing and the observed benefits need to be confirmed in humans but the early results are very promising, so watch this space!
What's the scientific evidence on hmb for these claims?
This is a busy area of research and hundreds of scientific studies have been so far on the effects of HMB, with more being published every month.
We list below small section of that research.
Arazi, H. et al. (2019) ‘β-Hydroxy- β-Methylbutyrate Free Acid Attenuates Oxidative Stress Induced by a Single Bout of Plyometric Exercise’, Frontiers in physiology. Front Physiol, 10. doi: 10.3389/FPHYS.2019.00776.
Asadi, A., Arazi, H. and Suzuki, K. (2017) ‘Effects of β-Hydroxy-β-methylbutyrate-free Acid Supplementation on Strength, Power and Hormonal Adaptations Following Resistance Training’, Nutrients. Nutrients, 9(12). doi: 10.3390/NU9121316.
Bieńko, M. et al. (2006) ‘Influence of beta-hydroxy beta-methylbutyrate (HMB) on the structural strength of bones.’, Medycyna Weterynaryjna. Polskiego Towarzystwa Nauk Weterynaryjnych, 62(8), pp. 963–965.
Cavallucci, V. and Pani, G. (2021) ‘The Leucine Catabolite and Dietary Supplement β-Hydroxy-β-Methyl Butyrate (HMB) as an Epigenetic Regulator in Muscle Progenitor Cells’, Metabolites. Metabolites, 11(8). doi: 10.3390/METABO11080512.
Duan, Y., Zhong, Y., Song, B., et al. (2019) ‘Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes’, Aging. Aging (Albany NY), 11(24), pp. 11922–11936. doi: 10.18632/AGING.102509.
Durkalec-Michalski, K. and Jeszka, J. (2015) ‘The efficacy of a β-hydroxy-β-methylbutyrate supplementation on physical capacity, body composition and biochemical markers in elite rowers: a randomised, double-blind, placebo-controlled crossover study’, Journal of the International Society of Sports Nutrition. Taylor & Francis, 12(1). doi: 10.1186/S12970-015-0092-9.
Durkalec-Michalski, K. and Jeszka, J. (2016) ‘The Effect of β-Hydroxy-β-Methylbutyrate on Aerobic Capacity and Body Composition in Trained Athletes’, Journal of strength and conditioning research. J Strength Cond Res, 30(9), pp. 2617–2626. doi: 10.1519/JSC.0000000000001361.
Durkalec-Michalski, K., Jeszka, J. and Podgórski, T. (2017) ‘The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study’, Nutrients. Nutrients, 9(7). doi: 10.3390/NU9070753.
Eley, H. L., Russell, S. T. and Tisdale, M. J. (2008a) ‘Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate’, American journal of physiology. Endocrinology and metabolism. Am J Physiol Endocrinol Metab, 295(6). doi: 10.1152/AJPENDO.90530.2008.
Fernández-Landa, J. et al. (2020) ‘Effect of Ten Weeks of Creatine Monohydrate Plus HMB Supplementation on Athletic Performance Tests in Elite Male Endurance Athletes’, Nutrients. Nutrients, 12(1). doi: 10.3390/NU12010193.
Fuller, J. C. and Rathmacher, J. A. (2022) ‘Acute dose toxicity evaluation of the food supplement calcium 3-hydroxy-3-methylbutyrate (HMB) in female Sprague Dawley rats’, Regulatory toxicology and pharmacology : RTP. Regul Toxicol Pharmacol, 130. doi: 10.1016/J.YRTPH.2022.105133.
Gepner, Y. et al. (2019) ‘Benefits of β-hydroxy-β-methylbutyrate supplementation in trained and untrained individuals’, Research in sports medicine (Print). Res Sports Med, 27(2), pp. 204–218. doi: 10.1080/15438627.2018.1533470.
Han, Z. et al. (2022) ‘Effect of Resistance Training Combined with Beta-Hydroxy-Beta-Methylbutyric Acid Supplements in Elderly Patients with Sarcopenia after Hip Replacement’, Orthopaedic surgery. Orthop Surg. doi: 10.1111/OS.13208.
Henning, P. C., Park, B. S. and Kim, J. S. (2014) ‘β-Hydroxy-β-methylbutyrate improves bone properties and attenuates the depression of protein synthesis during a simulated sustained operation’, Military medicine. Mil Med, 179(6), pp. 679–685. doi: 10.7205/MILMED-D-13-00421.
Hoffman, J. R. et al. (2016) ‘β-Hydroxy-β-methylbutyrate attenuates cytokine response during sustained military training’, Nutrition research (New York, N.Y.). Nutr Res, 36(6), pp. 553–563. doi: 10.1016/J.NUTRES.2016.02.006.
Holeček, M. (2017) ‘Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions’, Journal of Cachexia, Sarcopenia and Muscle. Wiley-Blackwell, 8(4), p. 529. doi: 10.1002/JCSM.12208.
Da Justa Pinheiro, C. H. et al. (2012) ‘Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle’, European journal of applied physiology. Eur J Appl Physiol, 112(7), pp. 2531–2537. doi: 10.1007/S00421-011-2224-5.
Kaczka, P. et al. (2019) ‘Mechanism of Action and the Effect of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Different Types of Physical Performance – A Systematic Review’, Journal of human kinetics. J Hum Kinet, 68(1), pp. 211–222. doi: 10.2478/HUKIN-2019-0070.
Knitter, A. E. et al. (2000) ‘Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run’, Journal of applied physiology (Bethesda, Md. : 1985). J Appl Physiol (1985), 89(4), pp. 1340–1344. doi: 10.1152/JAPPL.2000.89.4.1340.
Lin, Z., Zhao, Y. and Chen, Q. (2021) ‘Effects of oral administration of β-hydroxy β-methylbutyrate on lean body mass in older adults: a systematic review and meta-analysis’, European geriatric medicine. Eur Geriatr Med, 12(2), pp. 239–251. doi: 10.1007/S41999-020-00409-9.
Miramonti, A. A. et al. (2016) ‘Effects of 4 Weeks of High-Intensity Interval Training and β-Hydroxy-β-Methylbutyric Free Acid Supplementation on the Onset of Neuromuscular Fatigue’, Journal of strength and conditioning research. J Strength Cond Res, 30(3), pp. 626–634. doi: 10.1519/JSC.0000000000001140.
Park, B. S. et al. (2013) ‘HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise’, Metabolism: clinical and experimental. Metabolism, 62(12), pp. 1718–1729. doi: 10.1016/J.METABOL.2013.06.005.
Portal, S. et al. (2010) ‘Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices’, Journal of pediatric endocrinology & metabolism : JPEM. J Pediatr Endocrinol Metab, 23(7), pp. 641–650. doi: 10.1515/JPEM.2010.23.7.641.
Rahimi, M. H. et al. (2018) ‘The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis’, Journal of the American College of Nutrition. J Am Coll Nutr, 37(7), pp. 640–649. doi: 10.1080/07315724.2018.1451789.
Robinson, E. H. et al. (2014) ‘High-intensity interval training and β-hydroxy-β-methylbutyric free acid improves aerobic power and metabolic thresholds’, Journal of the International Society of Sports Nutrition. J Int Soc Sports Nutr, 11(1). doi: 10.1186/1550-2783-11-16.
Rowlands, D. S. and Thomson, J. S. (2009) ‘Effects of beta-hydroxy-beta-methylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: a meta-analysis’, Journal of strength and conditioning research. J Strength Cond Res, 23(3), pp. 836–846. doi: 10.1519/JSC.0B013E3181A00C80.
Sánchez-Gómez, Á. et al. (2022) ‘Effects of β-Hydroxy β-Methylbutyric Supplementation in Combination with Conservative Non-Invasive Treatments in Athletes with Patellar Tendinopathy: A Pilot Study’, International journal of environmental research and public health. Int J Environ Res Public Health, 19(1). doi: 10.3390/IJERPH19010471.
Shirvani, H. et al. (2020) ‘Effects of 2-week HMB-FA supplementation with or without eccentric resistance exercise on expression of some genes related to muscle protein turnover and serum irisin and IGF-1 concentrations’, Gene. Gene, 760. doi: 10.1016/J.GENE.2020.145018.
Silva, V. R. et al. (2017) ‘β-hydroxy-β-methylbutyrate free acid supplementation may improve recovery and muscle adaptations after resistance training: a systematic review’, Nutrition Research. Elsevier Inc., 45, pp. 1–9. doi: 10.1016/j.nutres.2017.07.008.
Simoncini, L. et al. (2021) ‘Effects of Nutritional Supplements on Judo-Related Performance: A Review’, Journal of human kinetics. J Hum Kinet, 77(1), pp. 81–96. doi: 10.2478/HUKIN-2021-0013.
Stout, J. R. et al. (2015) ‘β-Hydroxy-β-methylbutyrate (HMB) supplementation and resistance exercise significantly reduce abdominal adiposity in healthy elderly men’, Experimental gerontology. Exp Gerontol, 64, pp. 33–34. doi: 10.1016/J.EXGER.2015.02.012.
Suzuki, K. (2021) ‘Recent Progress in Applicability of Exercise Immunology and Inflammation Research to Sports Nutrition’, Nutrients. Nutrients, 13(12). doi: 10.3390/NU13124299.
Świetlicka, I. et al. (2021) ‘Fourier transform infrared microspectroscopy combined with principal component analysis and artificial neural networks for the study of the effect of β-hydroxy-β-methylbutyrate (HMB) supplementation on articular cartilage’, International Journal of Molecular Sciences. MDPI AG, 22(17), p. 9189. doi: 10.3390/IJMS22179189/S1.
Tatara, M. R., Krupski, W. and Majer-Dziedzic, B. (2017) ‘Bone mineral density changes of lumbar spine and femur in osteoporotic patient treated with bisphosphonates and beta-hydroxy-beta-methylbutyrate (HMB): Case report’, Medicine. Medicine (Baltimore), 96(41). doi: 10.1097/MD.0000000000008178.
Tsuchiya, Y. et al. (2019) ‘Two and Four Weeks of β-Hydroxy-β-Methylbutyrate (HMB) Supplementations Reduce Muscle Damage Following Eccentric Contractions’, Journal of the American College of Nutrition. J Am Coll Nutr, 38(4), pp. 373–379. doi: 10.1080/07315724.2018.1528905.
Tsuchiya, Y. et al. (2021) ‘Low Dose of β-Hydroxy-β-Methylbutyrate (HMB) Alleviates Muscle Strength Loss and Limited Joint Flexibility following Eccentric Contractions’, Journal of the American College of Nutrition. Routledge, 40(3), pp. 211–218. doi: 10.1080/07315724.2020.1752330.
Wilkinson, D. J. et al. (2018) ‘Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism’, Clinical nutrition (Edinburgh, Scotland). Clin Nutr, 37(6 Pt A), pp. 2068–2075. doi: 10.1016/J.CLNU.2017.09.024.
Wilson, J. M. et al. (2009) ‘Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage’, Nutrition & metabolism. Nutr Metab (Lond), 6. doi: 10.1186/1743-7075-6-6.
Wilson, J. M. et al. (2013) ‘International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)’, Journal of the International Society of Sports Nutrition. J Int Soc Sports Nutr, 10(1). doi: 10.1186/1550-2783-10-6.
Wilson, J. M. et al. (2014) ‘The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study’, European journal of applied physiology. Eur J Appl Physiol, 114(6), pp. 1217–1227. doi: 10.1007/S00421-014-2854-5.
Wu, H. et al. (2015) ‘Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis’, Archives of gerontology and geriatrics. Arch Gerontol Geriatr, 61(2), pp. 168–175. doi: 10.1016/J.ARCHGER.2015.06.020.
Yamada, A. K. et al. (2022) ‘Beta-hydroxy-beta-methylbutyrate associated with low-intensity exercise training improves skeletal muscle regeneration through the IGF-Akt pathway’, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. Braz J Med Biol Res, 55. doi: 10.1590/1414-431X2021E11597.
How come I’ve never heard of hmb before?
Can hmb cause harm? Are there side effects?
No, there are no harmful side-effects to taking HMB. It has been found that HMB can lower blood pressure and cholesterol levels, but for the vast majority of people this is not a problem. If you think it could be a problem for you then we would advise you to speak to your doctor.
Due to a lack of research around the topic you should also avoid taking HMB when pregnant or breastfeeding.
How many hmb capsules in a pack?
How much hmb should I take?
How soon will I get the benefits from hmb?
I already regularly take creatine/carnitine/amino acid/protein supplements - can i take hmb alongside those?
Since hmb is produced from leucine, can I just take (cheaper) leucine instead?
Consumption of such a high amount of leucine on its own, over a prolonged period, would enhance the oxidation and depletion of the other two BCAAs – valine and isoleucine. Such an imbalance in concentrations of the BCAA could have adverse effects on protein metabolism in the body.
For this reason HMB supplementation cannot be replaced by taking leucine.
Do I need to ‘cycle’ hmb? Can it be taken continuously?
However as with all other nutritional supplements, you may sometimes see good effects with pausing it after several months of continuous use, then restarting again after a few weeks.
Is hmb competition-legal?
How do I take hmb?
Mr Run’s HMB is dairy free, gluten free, egg and nut free, and is suitable for vegetarians and vegans. It contains no known allergens.
Proudly made in the uk
All our products are manufactured in the UK under strict quality controls and manufacturing guidelines in an ISO Class 8 Pharmaceutical room. The factory has been family-run for over 50 years and is MHRA, HFMA, AIB and FDA certified.
UK DELIVERIES: The expected total UK delivery time is 3-4 working days. All UK orders will be packed and dispatched within 24 hours of receipt and shipped via Royal Mail Tracker 48 service.
INTERNATIONAL DELIVERIES: Your order will be shipped within 24 hours of payment via Standard International carriage.
NOTE: Some countries, including EU countries, may charge extra import duties before releasing your shipment. Please check your country’s import rules before placing your order.